A POLIPOPROTEIN C3 (APOCIII) ANTAGONISTS AND METHODS OF THEIR USE TO REMOVE APOCIII INHIBITION OF LIPOPROTEIN LIPASE (LPL)

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专利权人:

发明人:

申请号：

EP14753632.0

公开号：

EP2958628A1

申请日:

2014.02.25

申请国别(地区):

EP

年份:

2015

代理人:

摘要：

Provided herein are methods of increasing lipoprotein lipase (LPL) activity, by inhibiting apolipoprotein C3 (ApoCIII), which removes the ApoCIII inhibition of LPL, and permits VLDL to be converted to LDL. Also provided are methods for treating or preventing a lipid metabolism disorder, such as type 2 diabetes by use of an ApoCIII antagonist. Also provided are screening methods to identify ApoCIII antagonists.

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中国工程科技知识中心

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