Urban A. Kiernan,David A. Phillips,Eric E. Niederkofler
申请号：
US14770395
公开号：
US09783600B2
申请日:
2014.02.25
申请国别(地区):
US
年份:
2017
代理人:
摘要：
Provided herein are methods of increasing lipoprotein lipase (LPL) activity, by inhibiting apolipoprotein C3 (ApoCIII), which removes the ApoCIII inhibition of LPL, and permits VLDL to be converted to LDL. Also provided are methods for treating or preventing a lipid metabolism disorder, such as type 2 diabetes by use of an ApoCIII antagonist. Also provided are screening methods to identify ApoCIII antagonists.
