rna antagonist compounds for inhibiting expression of mitochondrial glycerol-3-phosphate acyltransferase 1 (mtgpat1)

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专利权人:

SANTARIS PHARMA A/S

发明人:

ELLEN MARIE STRAARUP,MARIE LINDHOLM

申请号：

BRPI0915837

公开号：

BRPI0915837A2

申请日:

2009.06.24

申请国别(地区):

BR

年份:

2015

代理人:

摘要：

The present invention relates to oligomer compounds (oligomers), which target mtGPAT1mRNA in a cell, leading to reduced expression of mtGPAT1. Reduction of mtGPAT1 expression is beneficial for the treatment of certain medical disorders, such as overweight, obesity, fatty liver, hepatosteatosis, non alcoholic fatty liver disease (NAFLD), non alcoholic steatohepatitis (NASH), insulin resistance, and non insulin dependent diabetes mellitus (NIDDM).

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