Kevin P. DOOLEY,Rane A. HARRISON,Russell E. MCCONNELL,Ke XU,Damian J. HOUDE,Nikki ROSS,Sonya HAUPT,John D. KULMAN,Douglas E. WILLIAMS
申请号：
US16722884
公开号：
US20200222556A1
申请日:
2019.12.20
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to methods of preparing a therapeutic exosome using a protein newly-identified to be enriched on the surface of exosomes. Specifically, the present invention provides methods of using the proteins for affinity purification of exosomes. It also provides methods of localizing a therapeutic peptide on exosomes, and targeting exosomes to a specific organ, tissue or cell by using the proteins. The methods involve generation of surface-engineered exosomes that include one or more of the exosome proteins at higher density, or a variant or a fragment of the exosome protein.
