The present disclosure is directed to vaccines, antibodies, and/or immunogenic conjugate compositions targeting the SSEA3/SSEA4/GloboH associated epitopes (natural and modified) which elicit antibodies and/or binding fragment production useful for modulating the globo-series glycosphingolipid synthesis. The present disclosure relates to methods and compositions which can modulate the globo-series glycosphingolipid synthesis. Particularly, the present disclosure is directed to glycoenzyme inhibitor compound and compositions and methods of use thereof that can modulate the synthesis of globo-series glycosphingolipid SSEA3/SSEA4/GloboH in the biosynthetic pathway； particularly, the glycoenzyme inhibitors target the alpha-4GalT； beta-4GalNAcT-I； or beta-3GalT-V enzymes in the globo-series synthetic pathway. Moreover, the present disclosure is also directed to the method of using the compositions described herein for the treatment or detection of hyperproliferative diseases and/or conditions.本發明係關於靶向SSEA3/SSEA4/GloboH相關抗原決定基(天然及經修飾)之疫苗、抗體及/或免疫原性結合物組合物，其誘發抗體及/或結合片段產生用於調節球系列鞘醣脂合成。本發明係關於可調節球系列鞘醣脂合成之方法及組合物。特定言之，本發明係關於可調節生物合成路徑中之球系列鞘醣脂SSEA3/SSEA4/GloboH合成之醣酶抑制劑化合物及其組合物及使用方法；特定言之，醣酶抑制劑靶向球系列合成路徑中之α-1,4-半乳醣基轉移酶；β-1,4-N-乙醯半乳醣基轉移酶-I；或β-1,3-半乳醣基轉移酶-V。此外，本發明亦關於使用本文所述之組合物治療或偵測過度增生性疾病及/或病狀之方法。
