A nutritional supplement, comprising a combination of resveratrol, nicotinic acid or a nicotinic acid precursor, and D-ribose in nutritionally effective amounts； and wherein the combination is configured to increase Sirtuin 1 enzymatic activity and to initiate increased NAD+ production for sustaining said Sirtuin 1 enzymatic activity. In some examples the nutritional supplement is configured to target a certain physiologic stress and is delivered in treatments including a resveratrol dose of 30 mg per day, a nicotinic acid or nicotinic acid precursor dose of 30 mg per day, and a D-ribose dose of 3 grams per day.
