Ulrich Iserloh;Zhaoning Zhu;Andrew Stamford;Johannes H. Voigt
发明人:
Ulrich Iserloh,Zhaoning Zhu,Andrew Stamford,Johannes H. Voigt
申请号：
US12620291
公开号：
US08557798B2
申请日:
2009.11.17
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Disclosed are compounds of the formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt, solvate or ester thereof, wherein U, W, X, L, Y, M, Z, c, d, e, f, g, h, s, t, R1, R2, R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17 and R18 are as defined in the specification； and pharmaceutical compositions comprising the compounds of formula I.Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
