Ulrich Iserloh;Andrew Stamford;Xiaoxiang Liu;Robert D. Mazzola;Jared N. Cumming;Brian McKittrick;Zhaoning Zhu;Yusheng Wu;Ying Huang;Zhong-Yue Sun
发明人:
Yusheng Wu,Ulrich Iserloh,Jared N. Cumming,Xiaoxiang Liu,Robert D. Mazzola,Zhong-Yue Sun,Ying Huang,Andrew Stamford,Brian McKittrick,Zhaoning Zhu
申请号：
US13421396
公开号：
US08629155B2
申请日:
2012.03.15
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Disclosed are compounds of formula Ior a stereoisomer, tautomer, or pharmaceutically acceptable salt or solvate thereof, U, W, X, R1, R2, R6, R7, R30 and R31 are as described above in the specification.Also disclosed is the method of inhibiting aspartyl protease, and in particular, the methods of treating cardiovascular diseases, cognitive and neurodegenerative diseases. Also disclosed are methods of treating cognitive or neurodegenerative diseases using the compounds of formula I in combination with a cholinesterase inhibitor or a muscarinic m1 agonist or m2 antagonist.
