Mitoflavoscins: targeting flavin-containing enzymes eliminates cancer stem cells (CSCs) by inhibiting mitochondrial respiration

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专利权人:

Inc.;Lunella Biotech

发明人:

LISANTI, Michael P.,SOTGIA, Federica

申请号：

AU2018354143

公开号：

AU2018354143A1

申请日:

2018.10.23

申请国别(地区):

AU

年份:

2020

代理人:

摘要：

The present disclosure relates to compounds that bind to flavin-containing enzymes and inhibit mitochondrial function, referred to herein as mitoflavoscins. Methods of screening compounds for mitochondrial inhibition and anti-cancer properties are disclosed. Also described are methods of using mitoflavoscins to prevent or treat cancer, bacterial infections, and pathogenic yeast, as well as methods of using mitoflavoscins to provide anti-aging benefits. Specific mitoflavoscin compounds are also disclosed.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/