Systems and methods are disclosed for identifying anatomically relevant blood flow characteristics in a patient. One method includes: receiving, in an electronic storage medium, a patient-specific representation of at least a portion of vasculature of the patient having a lesion at one or more points； receiving values for one or more metrics of interest associated with one or more locations in the vasculature of the patient； receiving one or more observed lumen measurements of the vasculature of the patient； determining the location of a diseased region in the vasculature of the patient using the received values for the one or more metrics of interest, wherein the determination of the location includes predicting or receiving one or more healthy lumen measurements of the vasculature of the patient； determining the extent of the diseased region； and generating a visualization of at least the diseased region.
