Devices, systems, and methods for autoretroperfusion. In at least one embodiment of a perfusion system of the present disclosure, the system comprises a first catheter having a proximal end, a distal end, and a first lumen therethrough, the distal end configured for insertion into a luminal organ of a patient, a coupler defining an outlet port and a first port, the coupler configured to engage the proximal end of the first catheter at the outlet port and to receive blood from a blood supply through the first port, a first tube having a proximal end, a distal end, and a lumen therethrough, the distal end of the first tube configured to engage the first port of the coupler and to receive the blood from the blood supply, and a first flow regulator in communication with one or more of the coupler and the first tube, the first flow regulator operable to regulate a flow and/or a pressure of the blood through at least part of the system, wherein the system is configured to permit the blood from the blood supply to flow through the first tube, the coupler, and the first catheter into the patient to treat a patient condition.
