ROQUE NAVARRO, LOUDES TATIANA,MATEO DE ACOSTA DEL RIO, CRISTINA MARÍA,RODRIGUEZ GONZALEZ, MABEL CONSEJAL VEIGA NO 110,ROJAS DORANTES, GERTRUDIS,TALAVERA PEREZ, ARIEL,MORENO FRIAS, ERNESTO 5TA AVENIDA
申请号：
PL04728755
公开号：
PL1623997T3
申请日:
2004.04.22
申请国别(地区):
PL
年份:
2015
代理人:
摘要：
The invention essentially relates to the production of less immunogenic immunoglobulins by means of genetic engineering and, more specifically, to a monoclonal antibody recognizing antigens which contain the N-glycolil GM3 ganglioside but not other gangliosides of the N-glycolil or N-acetyl type, or the sulphated glycolipids. In particular the invention relates to peptides sequences encoding a recombinant monoclonal antibody against the N-glycolil GM3 ganglioside, or derivative fragments of the same. The invention further relates to pharmaceutical compositions containing the aforementioned antibody or fragments thereof and to the diagnostic or therapeutic use of same for breast cancer and melanoma.
