MEK1 Mutation Conferring Resistance to RAF and MEK Inhibitors

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专利权人:

Levi A. Garraway

发明人:

Levi A. Garraway,Caroline Emery,Nikhil Wagle

申请号：

US13701889

公开号：

US20130143911A1

申请日:

2011.06.09

申请国别(地区):

US

年份:

2013

代理人:

摘要：

Nucleic acids and proteins having a mutant MEK sequence, and methods concerning identification of patients having resistance to treatment with anti-cancer agents, specifically inhibitors of RAF or MEK are provided. Methods of treatment and for optimizing treatment for patients having a mutation in a MEK1 sequence are also provided.

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