Novel testosterone formulations are disclosed where testosterone is incorporated into a phospholipid/ cholesterol system to produce a proliposomal powder dispersion. The proliposomal powder dispersions of the invention may be formulated with phamarceutically acceptable excipients to form pharmaceutical compositions. Enterically coated oral dosage forms are disclosed as are methods of treatment for testosterone replacement therapy.揭示新穎的睪固酮調配物,其中睪固酮併入至磷脂質/膽固醇系統內來生產一種前體脂質體粉末分散劑。本發明的前體脂質體粉末分散劑可以調配與藥學上可接受的賦形劑一起來形成藥學組成物。揭示腸塗覆的口服睪固酮劑量形式,其為睪固酮補充治療法之治療方法。