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Listeria-based immunotherapy and methods of use thereof
专利权人:
Inc.;Advaxis
发明人:
Petit, Robert,Coder, Brandon
申请号:
AU2016369580
公开号:
AU2016369580A1
申请日:
2016.12.16
申请国别(地区):
AU
年份:
2018
代理人:
摘要:
The disclosure relates to the combined use of an immunotherapeutic composition comprising recombinant Listeria strains expressing a heterologous antigen fused to a truncated listeriolysin O (tLLO), a truncated ActA protein, or a PEST amino acid sequence and an antibiotic regimen, which may be sequentially administered in order to prevent the persistence, seeding of Listeria and/or formation of Listeria biofilms while allowing for an anti-tumor/anti-cancer or anti infectious disease immunotherapeutic response to take place. Disclosed are also methods of inducing an immune response, and treating, inhibiting, or suppressing cancer or tumors comprising administering the above composition.
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中国工程科技知识中心
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