Compound having phenylpyrimidone skeleton, pharmaceutical composition thereof, production method thereof and use thereof

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专利权人:

上海特化医薬科技有限公司;中国科学院上海薬物研究所;山東特▲法▼曼医薬原料有限公司

发明人:

劉 正,李 剣峰,楊 小軍,王 震,張 金鳳,朱 毅,田 広輝,金 青,瀋 競康,朱 維良,蒋 華良,瀋 敬山

申请号：

JP2011539873

公开号：

JP5479488B2

申请日:

2009.12.10

申请国别(地区):

JP

年份:

2014

代理人:

摘要：

The present invention relates to a class of phenylpyrimidone compounds, the pharmaceutical composition, the preparation method and the use thereof. More specifically, the present invention relates to a type of phenylpyrimidone compounds of the following formula I, the pharmaceutically acceptable salts or solvates thereof； and to the pharmaceutical composition as well as the preparation method of the said compounds. The said compounds of formula I according to the present invention can effectively inhibit type V phosphodiesterase (PDE5), and thus can be used for the treatment of various vascular disorders, such as male erectile dysfunction, pulmonary hypertension and the like.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/