Described herein is a kind of composition, it includes: the first Aripiprazole prodrug of (one) first groups particle The prodrug of the particle Aripiprazole of (two) second the second elastomers of group, different from the prodrug of the first Aripiprazole. At least the first and second prodrug group volume basis particle (Dv50) sizes are less than about 1000 nanometers. The method that the treatment method also described herein uses above-mentioned constituent, and manufacture aforementioned composition.
