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TREATMENT OF RETT SYNDROME
专利权人:
发明人:
申请号:
EP15767947.3
公开号:
EP3122187A1
申请日:
2015.03.24
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
Rett syndrome (RTT), a childhood neurological disorder that affects primarily females, may be treated by use of a galanthamine analog wherein the hydroxy group of galantamine is replaced of a carbarnate, carbonate or ester group and the methoxy group may be replaced by another alkoxy group of from two to six carbon atoms, a hydroxy group, hydrogen, an alkanoyloxy group or 2 to 10 carbon atoms, a benzoyloxy or substituted benzoyloxy group, a carbonate group of 1 to 10 carbon atoms or a carbamate group such as a mono alkyl or dialkyl or an aryl carbamate wherein the alkyl grottos or aryl groups contain from 1 to 10 carbons and the N-methyl group may be replaced by hydrogen, alkyl of 1 to 10 carbon atoms benzyl, cyclopropylmethyl group or a substituted or unsubstituted benzoyloxy group. Galantamine mon-alkylcarbarnates are particularly useful.
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