COMPOSITIONS AND USES FOR STABILISING TRANSTHYRETIN AND INHIBITING TRANSTHYRETIN MISFOLDING

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专利权人:

THE SCRIPPS RESEARCH INSTITUTE

发明人:

KELLY, JEFFERY W.,SEKIJIMA, YOSHIKI

申请号：

EP08014241

公开号：

EP1988397B8

申请日:

2003.12.19

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

Kinetic stabilization of the native state of transthyretin is an effective mechanism for preventing protein misfolding. Because transthyretin misfolding plays an important role in transthyretin amyloid diseases, inhibiting such misfolding can be used as an effective treatment or prophylaxis for such diseases. Treatment methods, screening methods, as well as specific transthyretin stabilizing compounds are disclosed.

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