MASON ALAN PAIRISH,SUVI TUULA MARJUKKA ORR,JOHN CHARLES KATH,MEHRAN JALAIE,GARY MICHAEL GALLEGO,HENGMIAO CHENG,PING CHEN
申请号：
ARP160102140
公开号：
AR105358A1
申请日:
2016.07.14
申请国别(地区):
AR
年份:
2017
代理人:
摘要：
1. Characteristic requirement 1: a compound, whose characteristic is formula (1) or a salt, and its medicament is acceptable, wherein X is n or 2；R1 is hydrogen or methyl； R2 is hydrogen, fluorine or chlorine； R3 is methyl or nh832222；This is n or cr830808；R8308es is hydrogen, cyanogen or fluorine； r83099 is hydrogen, methyl or cf8323；Z is NR⁶ or O； R⁶ is hydrogen or C₁₋₃ alkyl； R⁷ is hydrogen, C₁₋₄ alkyl, optionally substituted with 1, 2 or 3 substituents selected from the group consisting of fluorine, hydroxy and NH₂,-CH - (C cicloalquilo)-C (O) - (C alquilo)Alternative nh832222 selected from the fluorine group for option 1, 2 or 3；hidroxi metoxi y fenilo -C (O) - (C cicloalquilo)optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine and C₁₋₄ alkyl, - [(CH₂)] ₚ-C (O) - (4-5 membered heterocycloalkyl),optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine and C₁₋₄ alkyl, -C (O) - (5-6 membered heteroaryl),optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine and C₁₋₄ alkyl, - [(CH₂)] ₚ-C (O) - [N (R¹⁰) (R¹¹),-C (O) O- (C₁₋₄ alkyl),Alternative nh832222 selected from the fluorine group for option 1, 2 or 3；hidroxi metoxi y fenilo -C (O) O- (C cicloalquilo)optionally substituted with 1 or 2 substituents selected from the group consisting of fluorine and C₁₋₄ alkyl, -S (O) ₂- (C₁₋₄ alkyl),heterocicloalquilo de 4 - 6 miembros opcionalmente sustituido con 1 2 sustituyentes seleccionados del grupo que consiste en oxo y C alquilo o heteroarilo de 5 - 6 miembros opcionalmente sustituido con 1 2 sustituyentes seleccionados del grupo que consiste en oxo y C alquilo R es hidr geno ciano CF₃ or CH₂-O-C (O) - (C₁₋₃ alkyl),wherein C₁₋₃ alkyl is optionally substituted with hydroxy, methoxy or -O-P (O) (OH) ₂；R⁹ is fluorine or methyl； R¹⁰ is hydrogen or methyl； R¹¹ is C₁₋₄ alkyl, optionally substituted with 1, 2 or 3 fluorine atoms, provided that R¹⁰ and R¹¹ can
