Gyanu Lamichhane,William R. Bishai,Radhika Gupta,Marie Lavollay,Jean-Luc Mainardi,Michel Arthur
申请号：
US13283406
公开号：
US20120115835A1
申请日:
2011.10.27
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The peptidoglycan layer is a vital component of the bacterial cell wall, which comprises 4→3 and 3→3 transpeptide cross-linkages, the formation of which are catalyzed by D,D- and L,D-transpeptidases, respectively. Methods for the treatment of bacterial infections with agents that inhibit L,D-transpeptidases, either alone or in combination with D,D-transpeptidase inhibitors, are provided herein. Also provided are methods for the treatment of chronic stage tuberculosis with agents that inhibit enzyme with L,D-transpeptidase activity.
