SKINNER, MURRAY,HEWINGS, SIMON,PACKER, DUNCAN,POLAND, RICHARD
申请号:
CA2833319
公开号:
CA2833319A1
申请日:
2012.04.20
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
A method of preparing a composition comprising one or more antigens adsorbed to an amino acid wherein said method comprises: (i) mixing a solution of one or more antigens with a solution of the amino acid in an aqueous acid whilst neutralising the mixture of solutions, thereby forming an adsorbate comprising the one or more antigens and the amino acid; (ii) separating the adsorbate into a desired buffer by cross-flow filtration thereby forming said composition; and (iii) recovering said composition; wherein steps (i) to (iii) are performed in a sterile environment and within a closed system.