Skinner, Murray,Hewings, Simon,Packer, Duncan,Poland, Richard
申请号：
AU2012246087
公开号：
AU2012246087A1
申请日:
2012.04.20
申请国别(地区):
AU
年份:
2013
代理人:
摘要：
A method of preparing a composition comprising one or more antigens adsorbed to an amino acid wherein said method comprises: (i) mixing a solution of one or more antigens with a solution of the amino acid in an aqueous acid whilst neutralising the mixture of solutions, thereby forming an adsorbate comprising the one or more antigens and the amino acid (ii) separating the adsorbate into a desired buffer by cross-flow filtration thereby forming said composition and (iii) recovering said composition wherein steps (i) to (iii) are performed in a sterile environment and within a closed system.
