PACHUK CATHERINE J,SATISHCHANDRAN CHANDRASEKHAR,SIGG MARTIN D,MCCALLUS DANIEL E
申请号：
IN857/KOLNP/2007
公开号：
IN251758B
申请日:
2007.03.09
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Expression constructs comprising at least two different RNA polymerase III promoters, wherein each promoter is operably linked to a nucleic acid sequence encoding an RNA effector molecule, are disclosed herein. Further provided are expression constructs comprising multiple polymerase III promoters operably linked to sequences encoding short hairpin RNA molecules, which may comprise single and/or multiple fingers. The provided constructs are useful for in vivo delivery of RNA molecules effective in gene silencing, including of viral genes including HBV and HCV.
