This Hair is bright be related to 4- [(3- ethynyl phenyl) amino]-quinazo [6,7-b] -12- crown- 4 Which Suan Which and its new crystal form; The bright It of this Hair is related to the compound System Prepare method, and the Drug Wu Group containing the compound closes object, and the compound controls Treatment cancer Pro and controls Treatment method and Xiang Off Zhong Inter Body compound.本發明涉及4-[(3-乙炔基苯基)氨基]-喹唑啉并[6,7-b]-12-冠-4鹽酸鹽及其新的晶型;本發明還涉及所述化合物的製備方法,含有所述化合物的藥物組合物,所述化合物治療癌症的臨床治療方法以及相關的中間體化合物。