Robert Brown,Showan Nazhat,Vivek Mudera,Mike Wiseman
申请号：
US11631288
公开号：
US09101693B2
申请日:
2005.07.05
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention relates to cell-independent processes which mimic cellular bioremodelling and produce organized biomaterials which have mechanical properties and viable cell densities suitable for use as functional tissue implants. The biomaterials are produced by providing a gel comprising a matrix of scaffold fibers of and an interstitial fluid and plastically compacting the gel to produce the biomaterial. The biomaterials may comprise 3D structures such as layering, alignment and meso-scale zonal heterogeneities of cells and matrix which mimic native tissue structure. Biomaterials with biomimetic structure as described herein may be useful in a range of therapeutic applications.
