ピーター・ジョン・ネルソンＰｅｔｅｒ Ｊｏｎ ＮＥＬＳＯＮ;Peter Jon NELSON;Ｐｅｔｅｒ Ｊｏｎ ＮＥＬＳＯＮ
发明人:
ラルフ・フス,ピーター・ジョン・ネルソン
申请号：
JP2008531605
公开号：
JP5645362B2
申请日:
2006.09.20
申请国别(地区):
JP
年份:
2014
代理人:
摘要：
The present invention relates to the use of fusion constructs of glycosylphosphatidylinositol (GPI)-anchored tissue inhibitors of metalloproteinases (TIMPs) for the treatment of cancer. In one embodiment, the TIMP is linked to mucin followed by GPI for surface membrane presentation. The invention further relates to the use of TIMP-GPI or TIMP-mucin-GPI for inhibiting cancer cell proliferation both in vitro and in vivo. The GPI-anchored TIMP proteins are incorporated in the surface membrane of tumour cells and render tumour cells sensitive to FAS-induced apoptosis. This approach makes the GPI-anchored TIMPs useful as anti-cancer agents for the treatment of cancer, and, in particular, residual cancer after incomplete surgical resection of primary tumours in an individual.
