The present invention relates to adenoviral vectors wherein the viral capsid has been coated with polypeptides which are capable of stimulating a peptide specific immune response in a subject and uses thereof. Furthermore the present invention relates to methods of treating diseases e.g. cancer by adenoviral vectors which have been coated by polypeptides causing peptide specific immune response. Also the present invention relates to a method of coating adenoviral vectors by specific peptides as well as to a method of identifying those peptides suitable for coating the capsid of an adenoviral vector.
