Ekambar R. Kandimalla,Daqing Wang,Dong Yu,Ireneusz Nowak,Sudhir Agrawal
申请号：
US14149899
公开号：
US09260719B2
申请日:
2014.01.08
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The invention provides immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
