CIBLAGE DE CELLULES SOUCHES CANCEREUSES HYPOXIQUES (CSC) A L'AIDE DE DOXYCYCLINE : IMPLICATIONS POUR AMELIORER UNE THERAPIE ANTI-ANGIOGENIQUE

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专利权人:

INC.;LUNELLA BIOTECH

发明人:

SOTGIA, FEDERICA,LISANTI, MICHAEL P.

申请号：

CA3060509

公开号：

CA3060509A1

申请日:

2018.04.20

申请国别(地区):

CA

年份:

2018

代理人:

摘要：

The present disclosure relates to inhibitors of mitochondrialfunction. Methods of treating hypoxic cancer cells using anti-angiogenicagents and mitochondrial biogenesis inhibitors are disclosed.Tetracyclines, such as doxycycline, may serve as mitochondrial biogenesisinhibitors. Also described are methods of sensitizing hypoxic cancercells to one or more chemotherapies by administering a mitochondrialbiogenesis inhibitor with the chemotherapy.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/