Pharmaceutical formulations comprising 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2h-phthalazin-1-one or salt or solvate thereof in solid dispersion with a matrix polymer, medicaments comprising the same and methods of producing said solid dispersion
MICHAEL KARL BECHTOLD,CLAUDIA BETTINA PACKHAEUSER,JULIE KAY CAHILL,KATJA MAREN FASTNACHT,BERND HARALD LIEPOLD,KIERAN JAMES LENNON,BENEDIKT STEITZ
申请号：
IL21180911
公开号：
IL211809A
申请日:
2011.03.17
申请国别(地区):
IL
年份:
2014
代理人:
摘要：
The present invention relates to a pharmaceutical formulation comprising the drug 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one in a solid dispersion with a matrix polymer that exhibits low hygroscopicity and high softening temperature, such as copovidone. The invention also relates to a daily pharmaceutical dose of the drug provided by such a formulation. In addition, the invention relates to the use of a matrix polymer that exhibits low hygroscopicity and high softening temperature in solid dispersion with 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one for increasing the bioavailability of the drug.
