METHOD FOR PRODUCING (1S,4S,5S)-4-BROMO-6-OXABICYCLO[3.2.1]OCTAN-7-ONE

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专利权人:

Daiichi Sankyo Co. Ltd

发明人:

TAKAYANAGI, Yoshihiro,高柳 佳弘,FURUYA, Yukito,古屋 幸人,NAKAMURA, Yoshitaka,中村 嘉孝

申请号：

HK16109150.9

公开号：

HK1220977A

申请日:

2016.08.01

申请国别(地区):

HK

年份:

2017

代理人:

摘要：

It is an object of the present invention to provide a method for efficiently producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one (1), which is important as an intermediate compound for the production of an FXa-inhibiting compound. A method for producing (1S,4S,5S)-4-bromo-6-oxabicyclo[3.2.1]octan-7-one (1), which comprises treating an (R)-±-phenylethylamine salt of (S)-3-cyclohexene-1-carboxylic acid with 1,3-dibromo-5,5-dimethylhydantoin or N-bromosuccinimide in a solvent.

来源网站：

中国工程科技知识中心

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