SHIEH, DAR BIN,谢达斌,謝達斌,TSAI, TSUNG LIN,蔡宗霖,蔡宗霖,SU, WU CHOU,苏五洲,蘇五洲,CHUANG, KAO SHU,庄高树,莊高樹,HWU, JIH RU,胡纪如,胡紀如
申请号：
TW098123812
公开号：
TWI395594B
申请日:
2009.07.14
申请国别(地区):
TW
年份:
2013
代理人:
摘要：
The present invention discloses a nucleic acid cleavage composition, which is used to cleave a target nucleic acid. The nucleic acid cleavage composition includes a nano-particle, an oligonucleotide, and a nucleic acid cleavage agent. The oligonucleotide recognizes at least a part of the target nucleic acid. Then, the nucleic acid cleavage agent cleaves the target nucleic acid. The present invention also discloses a gene therapy by administering to a subject in need of the treatment an effective amount of the nucleic acid cleavage composition to cleave a target nucleic acid.本發明揭露一種核酸切割組合物,係可作用於一標的核酸,核酸切割組合物包括一奈米粒子、一寡核苷酸鏈、以及一核酸切割試劑,藉由寡核苷酸鏈識別一標的核酸之至少部分序列,再以核酸切割試劑切割標的核酸。另外,本發明亦揭露一種用於基因治療之方法,包括將有效量之上述核酸切割組合物投予至有需要之一個體以切割一標的核酸。1...核酸切割組合物11...奈米粒子12...寡核苷酸鏈13...核酸切割試劑A...區域
