Systems and methods to obtain parallel tissue conductances within luminal organs. In one method embodiment to obtain a parallel tissue conductance within a luminal organ of the present disclosure, the method comprises the steps of introducing at least part of a detection device into a luminal organ at a first location, the detection device having a detector, applying current to the detection device using a stimulator, and introducing a first signal having a first frequency and a second signal having a second frequency through the detection device.