PROBLEM TO BE SOLVED: To provide a novel compound having high selective inhibitory activity to sterol O-acyltransferase 2 (SOAT2) which is a drug target of preventive therapeutic agent for arteriosclerosis and/or lipid abnormality.SOLUTION: There is provided a compound represented by the formula (I), a salt thereof or a solvate of them. Rand Rto Rare each independently substituted/unsubstituted alkyl, substituted/unsubstituted cycloalkyl, substituted/unsubstituted aryl or the like, Rand Rform a double bond between carbons to which they bind or each independently is H, OH, substituted/unsubstituted alkyl, substituted/unsubstituted cycloalkyl, substituted/unsubstituted aryl or the like.SELECTED DRAWING: None【課題】動脈硬化症及び/又は脂質異常症の予防治療薬の薬剤標的であるステロールO-アシルトランスフェラーゼ2(SOAT2)に対して高い選択的阻害活性を有する新規化合物の提供。【解決手段】式(I)で表される化合物若しくはその塩、又はそれらの溶媒和物。[R1及びR4~R8は各々独立に置換/非置換のアルキル、置換/非置換のシクロアルキル、置換/非置換のアリール等;R2及びR3は、それらが結合する炭素の間で二重結合の形成、又は各々独立に、H、OH、置換/非置換のアルキル、置換/非置換のシクロアルキル、置換/非置換のアリール等。]【選択図】なし
