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2. A combined antiviral molecule composed of cloned 20h4.9 anti-41bb
专利权人:
F. HOFFMANN-LA ROCHE AG
发明人:
CLAUS, Christina,KLEIN, Christian,UMANA, Pablo,XU, Wei,FERRARA KOLLER, Claudia
申请号:
PE2019001290
公开号:
PE20191546A1
申请日:
2018.01.02
申请国别(地区):
PE
年份:
2019
代理人:
摘要:
It refers to a polymerized molecule to bisexual antimatter, including at least one polymerized antimatter domain name that can be specifically combined to 4-1BB, at least one polymerized antimatter domain name that can be combined to a target mobile antique and a Fc domain name. Union a 4-1BB domain name includes a heavy chain variable area, including (I) SEQ ID No.1, (II) cdr-h2 de SEQ ID No.2 and (III) CDR-H3 de SEQ ID No.3, and (I V) cdr-l1 de SEQ ID No.4, (V) cdr-l2 de SEQ ID No.5, and (VI) cdr-l3 de SEQ ID No.6. The target cell antigen was selected from the fiber activating protein (FAP).Sulfuric acid condom protein associated with melanomaEpidermal growth factor receptor (EFR),2. Carcinogenic antiques (CEA),CD19, CD20 or CD33 The Fc domain name of IgG, which is composed of the first and second teams, can establish partnerships in a stable way. This molecule is useful in the treatment of infection and cancer. He also mentioned a polynucleotide, an elite cell that encodes antibodies and a pharmacological synthesis that contains them.Referido a una molecula de union a antigeno biespecifica, que comprende al menos un dominio de union al antigeno capaz de unirse de manera especifica a 4-1BB, al menos un dominio de union al antigeno capaz de unirse a un antigeno de celula diana y un dominio Fc. Dicho dominio de union a 4-1BB, comprende una region variable de la cadena pesada, que comprende (i) CDR-H1 de SEQ ID NO: 1, (ii) CDR-H2 de SEQ ID NO: 2 y (iii) CDR-H3 de SEQ ID NO: 3; y una region variable de cadena ligera, que comprende (iv) CDR-L1 de SEQ ID NO: 4, (v) CDR -L2 de SEQ ID NO: 5, y (vi) CDR-L3 de SEQ ID NO: 6. El antigeno de celula diana se selecciona entre la proteina de activacion de fibroblastos (FAP), proteoglucano de sulfato de condroitina asociado a melanoma (MCSP), receptor de factor de crecimiento epidermico (EGFR), antigeno carcinoembrionario (CEA), CD19, CD20 o CD33. El dominio Fc de IgG formado por una primera y segunda subunidad capaces de asociars
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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