VARIANTES DE PERTUZUMAB ET LEUR EVALUATION

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专利权人:

INC.;GENENTECH

发明人:

GENNARO, LYNN A.,KAO, YUNG-HSIANG,ZHANG, YONGHUA

申请号：

CA3071678

公开号：

CA3071678A1

申请日:

2014.04.15

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present application discloses variants of Pertuzumab. In particular, itdiscloses: an unpairedcysteine variant comprising Cys23/Cys88 unpaired cysteines in one or bothvariable light domainsof Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS)of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. Theapplicationfurther discloses the isolated variants, compositions, pharmaceuticalcompositions, and articles ofmanufacture comprising the variants, as well as methods of making andcharacterizing the variantsand compositions thereof.

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