ГЕННАРО, Линн А. (US),КАО, Юн-Сян (US),ЧЗАН, Юнхуа (US)
申请号：
RU2019115089
公开号：
RU2019115089A
申请日:
2014.04.15
申请国别(地区):
RU
年份:
2019
代理人:
摘要：
The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof
