CHERUVALLATH, ZACHARIA,GWALTNEY, STEPHEN L.,JENNINGS, ANDREW JOHN,SABAT, MARK,STAFFORD, JEFFREY A.,TANG, MINGNAM,WANG, HAXIA
申请号：
PE0007562014
公开号：
PE13752014A1
申请日:
2009.05.15
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
Refers to Derivatives of pyrazole compounds of formula (i) wherein R1 is piridilo thiazolyl, pirazinilo, among others R2 and R4 are each h R3 is L - R18, where l is a - CH2 - R18 is tetrahydro - 2H - piran - 4 - ilo R5 is H, or Halo alkyl (C1 - C10), R6 and R7 are each Halo, alkyl (C1 - C10), among others.Preferred compounds are: 2 - (3 - (cyclopropylsulfonyl) - 1H pyrazol-1-yl) - N - (5 - metoxitiazolo [5,4-b] pyridin-2-yl) - 3 - (Tetrahydro - 2H - piran - 4-yl) propanamide n - (5 - clorotiazol - 2 - il) - 2 - (4 - (cyclopropylsulfonyl) - 1H pyrazol-1-yl) - 3 - (Tetrahydro - 2H - piran - 4-yl) propanamide among others. It also relates to a Pharmaceutical composition.These compounds are activators of glucokinase is useful in the treatment of diabetes, dyslipidemia, ObesitySE REFIERE A COMPUESTOS DERIVADOS DE PIRAZOL DE FORMULA (I) DONDE R1 ES TIAZOLILO, PIRAZINILO, PIRIDILO, ENTRE OTROS R2 Y R4 SON CADA UNO H R3 ES L-R18, EN DONDE L ES -CH2- R18 ES TETRAHIDRO-2H-PIRAN-4-ILO R5 ES H, HALO O ALQUILO(C1-C10) R6 Y R7 SON CADA UNO HALO, ALQUILO(C1-C10), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 2-(3-(CICLOPROPILSULFONIL)-1H-PIRAZOL-1-IL)-N-(5-METOXITIAZOLO[5,4-b]PIRIDIN-2-IL)-3-(TETRAHIDRO-2H-PIRAN-4-IL)PROPANAMIDA N-(5-CLOROTIAZOL-2-IL)-2-(4-(CICLOPROPILSULFONIL)-1H-PIRAZOL-1-IL)-3-(TETRAHIDRO-2H-PIRAN-4-IL)PROPANAMIDA ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ACTIVADORES DE GLUCOQUINASA SIENDO UTILES EN EL TRATAMIENTO DE DIABETES, DISLIPIDEMIA, OBESIDAD
