The present invention provides a medical composition, comprising a substituted biaryl compounds as shown in formula (I), or a pharmacologically acceptable salt as an effective component: (In the formula, the definitions of R1, W, R2, and Z are equal to the definitions in the claims and the specification.) The medical composition of the present invention has outstanding anti-inflammatory effect, and thereby can be used as an effective treatment and/or prophylaxis of chronic obstructive pulmonary disease.堤供一種醫藥組成物，其係含有通式(I)所示之取代聯芳基化合物或其在藥理上可容許的鹽作為有效成分：(式中，R1，W，R2及Z之定義同申請專利範圍及說明書)。本發明的醫藥組成物有優異的抗炎症作用，而為對慢性阻塞性肺疾病有用之治療藥及/或預防藥。
