The present invention relates to amino-substituted isothiazoles of general formula (I):in which A, R1 and R2 are as defined in the claims, to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of neoplasms, as a sole agent or in combination with other active ingredients.本發明係關於通式(I)之經胺基取代的異噻唑類:其中A、R1和R2係如申請專利範圍中所定義,製備該等化合物之方法、可用於製備該等化合物之中間化合物、包括該等化合物之醫藥組成物和組合物,以及該等化合物作為單一醫藥劑或與其他活性成份組成,用於製造醫藥組成物供治療或預防疾病,特別是腫瘤之用途。
