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3- (baryloxy) priopinic acid derivative
专利权人:
DAIICHI SANKYO COMPANY; LIMITED
发明人:
NISHI, TATSUYA,NAKAMOTO, YUMI,OCHIAI, YUICHI,KITAZAWA, RYOKO,HASEGAWA, MASASHI,SUSAKI, HIROSHI
申请号:
ES10811982
公开号:
ES2470329T3
申请日:
2010.08.27
申请国别(地区):
ES
年份:
2014
代理人:
摘要:
A compound of general formula (I): ** Formula ** [in which, R 1 represents a halogen atom, a cyano group, an amino group, a C 1-4 alkyl group, a halogenated C 1-4 alkyl group or a C1-4 alkoxy group, R2 represents a hydrogen atom, a halogen atom, a cyano group or a C1-4 alkyl group, R3 and R4, each independently, representing a hydrogen atom, a C1-4 alkyl group, a halogenated C1-4 alkyl group, a C1-4 alkoxy-C1-4 alkyl group or a hydroxy C1-4 alkyl group, or R3 and R4, together with the carbon atom to which they are attached, represent a cycloalkyl forming group C3-5, R5 represents a hydrogen atom, a halogen atom, a hydroxyl group, a nitro group, a C1-4 alkyl group or an amino group, R6 represents a hydrogen atom, a halogen atom or an alkyl group C1-4, R7 and R8, each independently, represent a hydrogen atom, a halogen atom or a C1-4 alkyl group, R9 and R10, each inde slope, they represent a hydrogen atom or a C1-4 alkyl group, R11 and R12, each independently, represent a hydrogen atom or a C1-4 alkyl group, or R11 and R12, together with the carbon atom to which they are together, they represent a group that forms C3-5 cycloalkyl, X represents an oxygen atom, a sulfur atom or a group represented by -CH (Rc) -, Rc represents a hydrogen atom or a hydroxyl group, Y represents an atom of nitrogen, or a group represented by>; = C (Ra) -, Ra represents a hydrogen atom, a halogen atom or a C1-4 alkyl group, and Z represents a nitrogen atom or a group represented by>; = CH -] or a pharmaceutically acceptable salt thereof.Un compuesto de fórmula general (I):**Fórmula** [en la que, R1 representa un átomo de halógeno, un grupo ciano, un grupo amino, un grupo alquilo C1-4, un grupo alquilo C1-4 halogenado o un grupo alcoxi C1-4, R2 representa un átomo de hidrógeno, un átomo de halógeno, un grupo ciano o un grupo alquilo C1-4, R3 y R4, cada uno independientemente, representan un átomo de hidrógeno, un grupo alquilo C1-4, un grupo alquilo C1-4 halogenado, un grupo alcoxi C1-4-a
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