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New thienopyrimidine derivatives, process for their preparation and pharmaceutical compositions containing them
专利权人:
Les Laboratoires Servier;Vernalis (R&D) Limited
发明人:
Kotschy, Andras,Szlávik, Zoltán,Csékei, Márton,Paczal, Attila,Szabó, Zoltán,SIPOS, Szabolcs,Radics, Gábor,Proszenyák, Agnes,Bálint, Balázs,Bruno, Alain,Geneste, Olivier,Davidson, James Edward Paul,Mur
申请号:
ES14199533
公开号:
ES2594377T3
申请日:
2014.12.22
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of formula (I): ** Formula ** where - A represents a linear or branched (C1-C6) alkyl group, a linear or branched (C2-C6) alkenyl group, a linear (C2-C6) alkynyl group or branched, a linear or branched (C1-C6) alkoxy group, a linear or branched (S-C6) alkyl-S-alkyl (C1-C6) alkyl group, a hydroxy, cyano group, - NR10R10 ', -Cy6 or a halogen atom, - R1, R2, R3, R4 and R5 represent, independently of each other, a hydrogen atom, a halogen atom, a linear or branched (C1-C6) alkyl group, a linear (C2-C6) alkenyl group or branched, a linear or branched (C2-C6) alkynyl group, a linear or branched (C1-C6) polyhaloalkyl, a hydroxy group, a linear or branched (C1-C6) alkoxy group, a -S-(C1-) alkyl group C6), cyano, nitro, -alkyl (C0-C6) -NR8R8 ', -O-Cy1, -alkyl (C0-C6) -Cy1, -alkenyl (C2-C6) -Cy1, -alkyl (C2-C6) -Cy1, -O-(C1-C6) alkyl -R9, -C (O) -OR8, -OC (O) -R8, -C (O) -NR8R8 ', -NR8-C (O) -R8' , -NR8-C (O) -OR8 ', -alkyl (C1-C6) -NR8-C (O) -R8', - SO2-NR8R8 ', -SO2-(C1-C6) alkyl, or the substituents of one of the pairs (R1, R2), (R2, R3), (R1, R3), (R4, R5), when inserted on two adjacent carbon atoms, together with the carbon atoms that carry them, an aromatic or non-aromatic ring composed of 5 to 7 ring members that can contain from one to three heteroatoms selected from oxygen, sulfur and nitrogen, being understood that the resulting ring may be substituted with a group selected from a linear or branched (C1-C6) alkyl group, -NR10R10 ', -C0-C6 alkyl -Cy1 or oxo, - X represents a carbon or a nitrogen atom , - R6 represents a hydrogen, a linear or branched (C1-C8) alkyl group, aryl, heteroaryl, (C1-C6) arylalkyl, (C1-C6) heteroarylalkyl, - R7 represents a linear (C1-C6) alkyl group or branched, linear or branched (C2-C6) alkenyl, linear or branched (C2-C6) alkynyl, -Cy3, -C1-C6-alkyl-Cy3, -C2-C6-alkenyl, -C2-alkyl C6) -Cy3, -Cy3-Cy4, - (C2-C6) alkynyl -O-Cy3, -Cy3-(C0-C6) -O-alkyl (C0-C6) -Cy4, a halogen atom, cyano, - C (O) -R11, -C (O ) -NR11R11 ', - R8 and R8'
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