LIU, Lian Zhu,MA, Tianwei,ZHANG, Haizhen,ZHOU, Jingye,HU, Zhi Long
申请号：
PE0014562017
公开号：
PE16502017A1
申请日:
2016.02.19
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
Refers to a compound of Formula 1, where r is NH or o r1 is - CF3, ocf3 or Halogen R2 is 1.4 - dimethyl - 1H imidazole - 5 - 1 - il cyclobutyl - 4 - methyl - 5 - 1H imidazole - il, among others R3 is C1 - Rent C3 or ciclopropilo and Each Asterisk designates a Chiral Centre.Preferred compounds are: cis - (Chiral) - N - [(2 - [5 - (1,4) - 1H imidazole - dimethyl - 5 - yl) - 4h-1,2,4-triazole - 3 - il] tetrahydro - 2H - piran - 4-yl] - N - methyl - 3 - (trifluoromethyl) benzamide CIS isomer 1 - (Chiral) - 3 - Chloro [2 - (N - [5 - (1,4) - 1H imidazole - dimethyl - 5 - yl) - 4h-1,2,4-triazole - 3 - il] tetrahydro - 2H - piran - 4-yl] - N - methyl - benzami Da isomer 1 among others. It also relates to a Pharmaceutical composition.These compounds are agonists gpr142, being useful in the reduction of glucose levels in the Blood or plasma.Referida a un compuesto de formula 1, donde: R es NH u O R1 es -CF3, -OCF3 o halogeno R2 es 1,4-dimetil-1H-imidazol-5-il 1-ciclobutil-4-metil-1H-imidazol-5-il entre otros R3 es alquilo C1-C3 o ciclopropilo y cada asterisco designa un centro quiral. Son compuestos preferidos: Cis-(quiral)-N-[(2-[5-(1,4-dimetil-1H-imidazol-5-il)-4H-1,2,4-triazol-3-il]tetrahidro-2H-piran-4-il]-N-metil-3-(trifluorometil)benzamida isomero 1 Cis-(quiral)-3-cloro-N-[(2-[5-(1,4-dimetil-1H-imidazol-5-il)-4H-1,2,4-triazol-3-il]tetrahidro-2H-piran-4-il]-N-metil-benzamida isomero 1 entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son agonistas de GPR142, siendo utiles en la reduccion de los niveles de glucosa en plasma o sangre.
