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INHIBIDORES NO NUCLEOSIDICOS DE LA TRANSCRIPTASA INVERSA
- 专利权人:
- MERCK CANADA INC.
- 发明人:
- BURCH, JASON,COTE, BERNARD,NGUYEN, NATALIE,LI, CHUN SING,ST-ONGE, MIGUEL,GAUVREAU, DANNY
- 申请号：
- PE0018232012
- 公开号：
- PE01582013A1
- 申请日:
- 2011.03.28
- 申请国别(地区):
- PE
- 年份:
- 2013
- 代理人:
- 摘要：
- Refers to compounds derived from 1 - [(2 - oxo - 4,5 dihydro - 1h-1,2,4-triazole - 3 - yl) methyl] - pyridin - 2 (1H) - one of formula (i) wherein R1 is alkyl, cycloalkyl (C1 - C10) (C3 - C8) or aryl R2 and R3 are each h, alkyl (C1 - C6), haloalquilo (C1 - C6), NO2, cycloalkyl (C3, C8), among others R4 is H, alkyl (C1 - C 6), halogen, fluoroalquilo (C1 - C6), among others R5 is H or alkyl (C1 - C6).Preferred compounds are: 3 - Chloro - 5 - ({1 - [(4 - methyl - 5 - oxo - 4,5 dihydro - 1h-1,2,4-triazole - 3 - yl) methyl] - 2 - oxo - 4 - (trifluoromethyl) - 1,2 - dihidropiridin - 3 - il} Oxy) benzonitrile 3 Chloro - 5 - ((4 - Chloro - [1 - (4 - methyl - 5 - oxo - 4,5 dihydro - 1h-1,2,4-triazole - 3 - yl) methyl] - 2 - oxo - 1.2 - dihidropiridin il} - 3 - 3 - (Oxy) benzonitrile {5 - B Romo - chlorine - 1 - [4 - (4 - methyl - 5 - oxo - 4,5 dihydro - 1h-1,2,4-triazole - 3 - yl) methyl] - 2 - oxo - 1Dihidropiridin - 2 - 3 - il) oxy) - 5 - clorobenzonitrilo among others. It also relates to a Pharmaceutical composition. These compounds are inhibitors of HIV reverse transcriptase, being useful in the treatment of HIV infectionSE REFIERE A COMPUESTOS DERIVADOS DE 1-[(5-OXO-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-3-IL)METIL]-PIRIDIN-2(1H)-ONA DE FORMULA (I) DONDE R1 ES ALQUILO(C1-C10), CICLOALQUILO(C3-C8) O ARILO R2 Y R3 SON CADA UNO H, ALQUILO(C1-C6), HALOALQUILO(C1-C6), NO2, CICLOALQUILO(C3-C8), ENTRE OTROS R4 ES H, ALQUILO(C1-C6), HALOGENO, FLUOROALQUILO(C1-C6), ENTRE OTROS R5 ES H O ALQUILO(C1-C6). SON COMPUESTOS PREFERIDOS: 3-CLORO-5-({1-[(4-METIL-5-OXO-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-3-IL)METIL]-2-OXO-4-(TRIFLUOROMETIL)-1,2-DIHIDROPIRIDIN-3-IL}OXI)BENZONITRILO 3-CLORO-5-({4-CLORO-1-[(4-METIL-5-OXO-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-3-IL)METIL]-2-OXO-1,2-DIHIDROPIRIDIN-3-IL}OXI)BENZONITRILO 3-({5-BROMO-4-CLORO-1-[(4-METIL-5-OXO-4,5-DIHIDRO-1H-1,2,4-TRIAZOL-3-IL)METIL]-2-OXO-1,2-DIHIDROPIRIDIN-3-IL}OXI)-5-CLOROBENZONITRILO ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
