ASHLEY ANNE KATANA,JAMES G. TAYLOR,HYUNG PYUN,ADAM JAMES JUNG - SCHRIER,CHINH VIET TRAN,TERESA ALEJANDRA TREJO MARTIN,KYLA BJORNSON,JOHN O. LINK,KAPIL KUMAR KARKI,DARRYL KATO,JEROMY J. COTTELL,DUSTIN
申请号：
ARP130102368
公开号：
AR091661A1
申请日:
2013.07.02
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: A compound characterized in that it has the formula (1) or a stereoisomer, or a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein: J is C₁₋₄ alkyl or C₃₋₆ carbocyclyl,wherein the C₁₋₄ alkyl or C₃₋₆ carbocyclyl is optionally substituted with 1-4 halogen, -OH, aryl or cyano； the T ring is C₃₋₅ carbocyclylene that binds to L and the rest of the compound of the formula (1) through two adjacent carbons, wherein said C₃₋₅ carbocyclylene is optionally substituted with C₁₋₄ alkyl,Halogenated tar c83218323；halogen, -OH, or cyano, or the T-ring is bicyclic C₅₋₈ carbocyclylene that binds to L and the rest of the compound of formula (1) through two adjacent carbons, or C₃₋₆ carbocyclylene that binds to L and the rest of the compound of the formula (1) through two adjacent carbons, wherein said C₃₋₆ carbocyclene is optionally substituted with C₁₋₄ alkyl or C₁₋₃ haloalkyl；L is c832233 asphalt；a. Alquenileno c83323238s 833126o - (ch832222) 832323 cyclopropene -,optionally substituted with 1-4 halogen, -OH, or cyano； Q is C₂₋₄ alkyl or C₃₋₆ carbocyclyl optionally substituted with C₁₋₃ alkyl,a. E is c83183323 or alquenilo c833228331；optionally substituted with 1-3 halogen； W is H, -OH, -O-C₁₋₃ alkyl,-O-halide c8321c83183323；a. Halogen or cyanogen； and z274919 are h or c832131；Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1) o un estereoisómero, o una mezcla de estereoisómeros, o una sal aceptable farmacéuticamente del mismo, donde: J es alquilo C₁₋₄ o carbociclilo C₃₋₆, donde el alquilo C₁₋₄ o carbociclilo C₃₋₆ está opcionalmente sustituido con 1 - 4 halógeno, -OH, arilo o ciano； el anillo T es carbociclileno C₃₋₅ que se une a L y al resto del compuesto de la fórmula (1) a través de dos carbonos adyacentes, donde dicho carbociclileno C₃₋₅ está opcionalmente sustituido con alquilo C₁₋₄, haloalquilo C₁₋₃, halógeno, -OH, o ciano, o el anillo T es carbociclileno C₅₋₈ bicíclico que se une a L y al resto del compuesto de la f
