Disclosed herein is a modular composition comprising 1) an oligonucleotide 2) one or more tetraGalNAc ligands of Formula (I), which may be the same or different optionally, 3) one or more linkers, which may be the same or different 4) one or more peptides independently selected from Table 3, which may be the same or different and optionally, 5) one or more targeting ligands, solubilizing agents, pharmacokinetics enhancing agents, lipids, and/or masking agents.本發明揭示包含以下之模組化組合物:1)寡核苷酸;2)一或多個式(I)之四GalNAc配體,其可相同或不同;視情況,3)一或多個連接體,其可相同或不同;4)一或多個獨立地選自表3之肽,其可相同或不同;及視情況,5)一或多個靶向配體、增溶劑、藥物動力學增強劑、脂質及/或掩蔽劑。
