ACOSTA, VICTOR MARCEL,BAJAJ, VIKRAM SINGH,HOMYK, ANDREW,PEETERS, ERIC,THOMPSON, JASON DONALD
申请号：
TW104105723
公开号：
TW201536256A
申请日:
2015.02.17
申请国别(地区):
TW
年份:
2015
代理人:
摘要：
An imaging agent for detecting analytes in a biological environment includes functionalized, silicon vacancy center-containing nanodiamonds. Individual nanodiamonds of the imaging agent include at least one silicon vacancy center. The at least one silicon vacancy center can emit light having a wavelength in a narrow band in response to illumination having any wavelength in a wide range of wavelengths. The nanodiamonds are functionalized to selectively interact with an analyte of interest. The nanodiamonds can additionally include other color centers, and the imaging agent can include a plurality of sets of nanodiamonds having detectably unique ratios of silicon vacancy centers to other color centers. The silicon vacancy centers in the nanodiamonds can have a preferred orientation enabling orientation tracking of individual nanodiamonds or other applications. A method for detecting properties of the analyte of interest by interacting with the imaging agent is also provided.本發明提供一種用於偵測一生物環境中之分析物之成像劑，其包含經官能化、含矽空位中心之奈米鑽石。該成像劑之個別奈米鑽石包含至少一矽空位中心。該至少一矽空位中心可回應於具有在一廣泛波長範圍中之任何波長之照明而發射具有在一窄頻帶中之一波長之光。該等奈米鑽石經官能化以與所關注之一分析物選擇性地相互作用。該等奈米鑽石可額外包含其他色彩中心，且該成像劑可包含具有矽空位中心對其他色彩中心之可偵測獨有比率之複數組奈米鑽石。該等奈米鑽石中之該等矽空位中心可具有實現個別奈米鑽石之定向追蹤或其他應用之一較佳定向。亦提供一種用於藉由與該成像劑相互作用而偵測所關注之該分析物之性質之方法。
