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RHC STIMULANTS AND THEIR COMBINATIONS FOR TREATMENT OF HEARING DISORDERS
专利权人:
БАЙЕР ШЕРИНГ ФАРМА АКЦИЕНГЕЗЕЛЬШАФТ (DE)
发明人:
ЗАНДНЕР Петер (DE),ШТАШ Йоханнес-Петер (DE)
申请号:
RU2010150451/15
公开号:
RU2010150451A
申请日:
2009.04.28
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. A pharmaceutical composition for treating a disease belonging to a group of diseases consisting of a hearing impairment related to impaired ability to perceive sound, including partial hearing loss, total hearing loss, deafness (complete or partial) and ringing in the ears, in mammals, containing therapeutic an agent that regulates the activity of soluble guanylate cyclase. ! 2. A pharmaceutical composition for treating a disease belonging to a group of diseases consisting of a hearing impairment related to impaired ability to perceive sound, including partial hearing loss, total hearing loss, deafness (complete or partial) and ringing in the ears in mammals containing stimulants guanylate cyclase (rHC) and / or activators of rHC. ! 3. A pharmaceutical composition for treating a disease belonging to a group of diseases consisting of a hearing impairment related to impaired ability to perceive sound, including partial hearing loss, total hearing loss, deafness (complete or partial) and tinnitus in mammals, preferably represents is a compound selected from the group consisting of 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5- (4-morpholinyl) -4,6-pyrimidinediamine (1), 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5- (4-pyridinyl) -4-pyrimidinamine (2), methyl-4 6-d amino-2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5-pyrimidinyl- (methyl) carbamate (3), methyl-4,6-diamino 2- [1- (2-fluorobenzyl) -1H-pyrazolo [3,4-b] pyridin-3-yl] -5-pyrimidinyl carbamate (4) and / or 4 - ({(4-carboxybutyl) [2 - (2 - {[4- (2-phenylethyl) benzyl] oxy} phenyl) ethyl] amino} methyl) benzoic acid (5). ! 4. The use of a stimulator and / or activator of the RGC to obtain1. Фармацевтическая композиция для лечения заболевания, принадлежащего к группе заболеваний, состоящей из нарушения слуха, относящегося к нарушению способности воспринимать звук, включая частичную потерю слуха, полную потерю слуха, глухоту (полную или частичную) и звон в ушах,
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