PROBLEM TO BE SOLVED: To allow administration of a small particle oxygen carrier to an ischemic stroke patient by suppressing generation of administration-related reactions.SOLUTION: The invention relates to an ischemic stroke therapeutic agent for intravenously administering a liquid preparation in which a heme protein as an active ingredient is sealed in a particulate carrier having a smaller average particle diameter than that of an erythrocyte at a rate of less than 2.4 (mg/kg)/min for a first 15 minutes from the start of the administration, and at a rate of 2.4 (mg/kg)/min or more thereafter.COPYRIGHT: (C)2013,JPO&INPIT【課題】投与時関連反応の発生を抑制して、小粒子酸素運搬体の虚血性脳卒中の患者への投与を可能にする。【解決手段】赤血球よりも小さい平均粒子径の粒子状担体に有効成分のヘムタンパク質が内封された液状製剤を、投与開始から15分間は2.4(mg/kg)/min未満の速度で、その後2.4(mg/kg)/min以上の速度で静脈内投与する虚血性脳卒中治療薬。【選択図】なし
